What are the referral criteria for a gastroenterology specialist in cases of suspected Celiac disease?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 14 August 2025Updated: 14 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Refer young people and adults with positive serological test results to a gastrointestinal specialist for endoscopic intestinal biopsy to confirm or exclude coeliac disease .

Refer children with positive serological test results to a paediatric gastroenterologist or paediatrician with a specialist interest in gastroenterology for further investigation for coeliac disease .

Refer people with negative serological test results to a gastrointestinal specialist for further assessment if coeliac disease is still clinically suspected .

Refer if there are persistent symptoms, including diarrhoea, abdominal pain, weight loss, fatigue or unexplained anaemia, despite exclusion of gluten exposure .

Refer if there is suspected non-responsive or refractory coeliac disease .

Refer if there are concerns about ongoing gluten exposure, nutritional deficiencies, or growth impairment .

Refer urgently if there is suspicion of serious complications such as malignancy (e.g., lymphoma, small bowel adenocarcinoma, or pancreatic cancer) .

Educational content only. Always verify information and use clinical judgement.