What are the first-line treatment options for adults with allergic rhinitis in primary care?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 14 August 2025Updated: 14 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

First-line treatment options for adults with allergic rhinitis in primary care include intranasal corticosteroids and antihistamines (intranasal or non-sedating oral antihistamines), used either alone or in combination .

Intranasal corticosteroids are considered the most effective treatment for allergic rhinitis .

Options include intranasal mometasone furoate, fluticasone furoate, or fluticasone propionate, which have minimal systemic absorption .

For mild, intermittent, or both types of allergic rhinitis, antihistamines (intranasal or oral non-sedating) are suggested, especially in children, while adults may be offered any first-line treatment .

In cases of moderate to severe or persistent allergic rhinitis, an intranasal corticosteroid or the combination of an intranasal corticosteroid with an intranasal antihistamine is recommended .

Patients should be advised to start treatment two weeks before known allergen exposure, such as pollen seasons, and to continue until the exposure ends or symptoms resolve .

Educational content only. Always verify information and use clinical judgement.