A 55-year-old man with PSC develops recurrent cholangitis despite UDCA therapy. MRCP shows a dominant stricture in the common hepatic duct. CA 19-9 is...

Question

A 55-year-old man with PSC develops recurrent cholangitis despite UDCA therapy. MRCP shows a dominant stricture in the common hepatic duct. CA 19-9 is 120 U/mL. Brush cytology at ERCP is inconclusive. What investigation has the highest sensitivity for detecting cholangiocarcinoma in PSC?

Accepted Answer

FISH (fluorescence in situ hybridisation) on biliary brushings

Answer

CT with contrast

Answer

Liver biopsy

Answer

PET-CT

Answer

Serum CA 19-9 alone

uk-sce-gastroenterology MCQ (SBA): Cholangiocarcinoma

A 55-year-old man with PSC develops recurrent cholangitis despite UDCA therapy. MRCP shows a dominant stricture in the common hepatic duct. CA 19-9 is 120 U/mL. Brush cytology at ERCP is inconclusive. What investigation has the highest sensitivity for detecting cholangiocarcinoma in PSC?