A 54-year-old woman with a 10-year history of rheumatoid arthritis has persistent moderate disease activity despite optimal methotrexate therapy. She ...

Question

A 54-year-old woman with a 10-year history of rheumatoid arthritis has persistent moderate disease activity despite optimal methotrexate therapy. She has no contraindications to biologic agents. According to Canadian Rheumatology Association recommendations, what is the most appropriate next pharmacologic step?

Accepted Answer

Add a tumour necrosis factor (TNF) inhibitor

Answer

Switch to long-term oral prednisone alone

Answer

Add hydroxychloroquine and sulfasalazine only

Answer

Stop methotrexate and observe

Answer

Treat with NSAIDs alone

ca-mccqe1 MCQ (SBA): Rheumatoid arthritis