A 72-year-old woman with major depressive disorder and no psychotic features has failed two adequate trials of SSRIs. According to CANMAT 2023 guideli...

Question

A 72-year-old woman with major depressive disorder and no psychotic features has failed two adequate trials of SSRIs. According to CANMAT 2023 guidelines, which next step is most appropriate?

Accepted Answer

Augment with a second-generation antipsychotic such as quetiapine

Answer

Switch to another SSRI from the same class

Answer

Increase SSRI dose beyond recommended maximum

Answer

Start long-term benzodiazepine monotherapy

Answer

Recommend no further pharmacotherapy and focus on watchful waiting

ca-mccqe1 MCQ (SBA): Treatment-resistant major depressive disorder

A 72-year-old woman with major depressive disorder and no psychotic features has failed two adequate trials of SSRIs. According to CANMAT 2023 guidelines, which next step is most appropriate?