A 38-year-old woman presents with several months of bloating and intermittent diarrhoea. She reports weight loss of 4 kg. There is no rectal bleeding....

Question

A 38-year-old woman presents with several months of bloating and intermittent diarrhoea. She reports weight loss of 4 kg. There is no rectal bleeding. Physical examination is unremarkable. Laboratory tests show iron deficiency with ferritin 10 µg/L. According to Canadian gastroenterology practice, which initial investigation is most appropriate to evaluate for coeliac disease?

Accepted Answer

Total serum IgA and IgA tissue transglutaminase antibody

Answer

Colonoscopy with random biopsies

Answer

Upper endoscopy without biopsies

Answer

IgM anti-endomysial antibody

Answer

HLA typing for HLA-DQ2 and HLA-DQ8

ca-mccqe1 MCQ (SBA): Celiac disease evaluation