A 45-year-old woman presents with fatigue, pruritus, and jaundice. Labs show elevated alkaline phosphatase and positive anti-mitochondrial antibodies....

Question

A 45-year-old woman presents with fatigue, pruritus, and jaundice. Labs show elevated alkaline phosphatase and positive anti-mitochondrial antibodies. Ultrasound shows no biliary obstruction. What is the most appropriate initial pharmacologic treatment?

Accepted Answer

Ursodeoxycholic acid

Answer

Azathioprine

Answer

Prednisone

Answer

Cholestyramine alone

Answer

Liver transplantation

us-abfm MCQ (SBA): Primary Biliary Cholangitis

A 45-year-old woman presents with fatigue, pruritus, and jaundice. Labs show elevated alkaline phosphatase and positive anti-mitochondrial antibodies. Ultrasound shows no biliary obstruction. What is the most appropriate initial pharmacologic treatment?