A 35-year-old with watery diarrhea after recent antibiotics tests positive for C. difficile toxin. No severe features (WBC 9,500/µL; creatinine normal...

Question

A 35-year-old with watery diarrhea after recent antibiotics tests positive for C. difficile toxin. No severe features (WBC 9,500/µL; creatinine normal). Preferred initial therapy?

Accepted Answer

Fidaxomicin 200 mg PO BID × 10 days

Answer

Oral vancomycin 125 mg QID × 10 days

Answer

Metronidazole 500 mg PO TID × 10 days

Answer

Probiotics only

Answer

No antibiotics unless WBC >15,000/µL

us-abim MCQ (SBA): Clostridioides difficile Infection

A 35-year-old with watery diarrhea after recent antibiotics tests positive for C. difficile toxin. No severe features (WBC 9,500/µL; creatinine normal). Preferred initial therapy?