A 58-year-old man with recurrent gout flares and stage 3 CKD has serum urate 9.0 mg/dL between flares. Which urate‑lowering approach is guideline‑conc...

Question

A 58-year-old man with recurrent gout flares and stage 3 CKD has serum urate 9.0 mg/dL between flares. Which urate‑lowering approach is guideline‑concordant?

Accepted Answer

Start allopurinol ≤100 mg daily (≤50 mg if CKD) and titrate to serum urate

Answer

Delay urate‑lowering therapy until ≥3 flares per year

Answer

Start febuxostat 80 mg daily as first‑line

Answer

Start allopurinol 300 mg daily immediately

Answer

Start probenecid 500 mg twice daily as first‑line

us-abim MCQ (SBA): Gout

A 58-year-old man with recurrent gout flares and stage 3 CKD has serum urate 9.0 mg/dL between flares. Which urate‑lowering approach is guideline‑concordant?