A 64-year-old man with diabetes and a plantar ulcer probing to bone has MRI-confirmed osteomyelitis; cultures show MSSA and streptococci; no Pseudomon...

Question

A 64-year-old man with diabetes and a plantar ulcer probing to bone has MRI-confirmed osteomyelitis; cultures show MSSA and streptococci; no Pseudomonas risk factors. Optimal initial antibiotic strategy?

Accepted Answer

Narrow-spectrum beta-lactam targeting gram-positive cocci for ~6 weeks

Answer

Empiric anti-Pseudomonal triple therapy for 6 weeks

Answer

Amoxicillin/clavulanate plus clindamycin for 3 days then stop

Answer

Immediate oral fluoroquinolone monotherapy for 10 days

Answer

Topical antibiotics only

us-abim MCQ (SBA): Diabetic Foot Osteomyelitis

A 64-year-old man with diabetes and a plantar ulcer probing to bone has MRI-confirmed osteomyelitis; cultures show MSSA and streptococci; no Pseudomonas risk factors. Optimal initial antibiotic strategy?