A 45-year-old with persistent depression after two adequate SSRI trials seeks guidance. Which next step aligns with evidence-based recommendations?...

Question

A 45-year-old with persistent depression after two adequate SSRI trials seeks guidance. Which next step aligns with evidence-based recommendations?

Accepted Answer

Switch to esketamine/ketamine therapy under supervision

Answer

Continue same SSRI indefinitely

Answer

Add benzodiazepine long-term

Answer

Recommend St. John's wort

Answer

Stop medications and try psychotherapy only

us-abim MCQ (SBA): Treatment-Resistant Depression