A 52-year-old with recurrent gout flares (3/year) and tophi has eGFR 50 mL/min/1.73 m². Best first-line urate-lowering therapy?...

Question

A 52-year-old with recurrent gout flares (3/year) and tophi has eGFR 50 mL/min/1.73 m². Best first-line urate-lowering therapy?

Accepted Answer

Allopurinol, start low (e.g., 100 mg daily) and titrate to urate

Answer

Probenecid

Answer

Febuxostat starting at full dose

Answer

Allopurinol PRN during flares only

Answer

Pegloticase infusions

us-abim MCQ (SBA): Gout