A 58-year-old woman with gout has two flares this year and serum urate 8.9 mg/dL, eGFR 65. What is the recommended urate-lowering therapy strategy?...

Question

A 58-year-old woman with gout has two flares this year and serum urate 8.9 mg/dL, eGFR 65. What is the recommended urate-lowering therapy strategy?

Accepted Answer

Start allopurinol 100 mg daily and titrate to serum urate

Answer

Start febuxostat only if HLA-B*58:01 positive

Answer

Delay ULT until ≥3 flares/year

Answer

Start probenecid as first-line regardless of renal function

Answer

Begin colchicine only during flares; no ULT

us-abim MCQ (SBA): Gout-ULT Initiation