A cisplatin-fit adult with operable muscle-invasive urothelial bladder cancer is planned for radical surgery. Which perioperative immunotherapy sequen...

Question

A cisplatin-fit adult with operable muscle-invasive urothelial bladder cancer is planned for radical surgery. Which perioperative immunotherapy sequence has a specific NICE recommendation alongside the conventional neoadjuvant regimen?

Accepted Answer

Add durvalumab to neoadjuvant gemcitabine–cisplatin, then continue durvalumab adjuvantly

Answer

Give durvalumab alone before surgery, then gemcitabine–cisplatin alone after surgery

Answer

Give durvalumab with carboplatin before surgery, then pembrolizumab after surgery

Answer

Add nivolumab to neoadjuvant gemcitabine–cisplatin, then omit adjuvant systemic treatment

Answer

Reserve durvalumab with gemcitabine–cisplatin until after radical surgery

Postoperative VTE Prophylaxis — MRCP Part 1 MCQ

A cisplatin-fit adult with operable muscle-invasive urothelial bladder cancer is planned for radical surgery. Which perioperative immunotherapy sequence has a specific NICE recommendation alongside the conventional neoadjuvant regimen?