A 72-year-old with CAP started on clarithromycin develops tinnitus and rising creatinine on gentamicin. What interaction is concerning?...

Question

A 72-year-old with CAP started on clarithromycin develops tinnitus and rising creatinine on gentamicin. What interaction is concerning?

Accepted Answer

Macrolide + gentamicin increases ototoxicity

Answer

ACEI + gentamicin causes hyperkalaemia

Answer

Metformin + clarithromycin causes lactic acidosis

Answer

Clarithromycin reduces gentamicin clearance via CYP3A4

Answer

No interaction

prescribing safety assessment MCQ (SBA): Ototoxicity risk