A 58-year-old man with chronic HCV is starting sofosbuvir/velpatasvir. Which common PPI interaction advice is correct?...

Question

A 58-year-old man with chronic HCV is starting sofosbuvir/velpatasvir. Which common PPI interaction advice is correct?

Accepted Answer

Avoid high-dose PPIs; if needed, take PPI 4 hours after velpatasvir

Answer

Increase PPI dose to improve absorption

Answer

No interaction with PPIs

Answer

Stop antiviral therapy instead

Answer

Take PPI at the same time

prescribing safety assessment MCQ (SBA): Hepatitis C Pharmacology