A 50-year-old patient with rheumatoid arthritis, well-controlled on methotrexate 15mg weekly and folic acid 5mg weekly, requires treatment for an infe...

Question

A 50-year-old patient with rheumatoid arthritis, well-controlled on methotrexate 15mg weekly and folic acid 5mg weekly, requires treatment for an infection. Which antibiotic should generally be avoided due to a significant interaction with methotrexate, increasing the risk of methotrexate toxicity (e.g., myelosuppression)?

Accepted Answer

Trimethoprim

Answer

Amoxicillin

Answer

Clarithromycin

Answer

Doxycycline

Answer

Ciprofloxacin

ukmla MCQ (SBA): Drug Interaction (Methotrexate/Trimethoprim)