A patient taking Simvastatin 40mg at night for hypercholesterolaemia is started on Itraconazole for a fungal nail infection. What is the primary pharm...

Question

A patient taking Simvastatin 40mg at night for hypercholesterolaemia is started on Itraconazole for a fungal nail infection. What is the primary pharmacokinetic interaction of concern?

Accepted Answer

Increased risk of myopathy and rhabdomyolysis

Answer

Decreased absorption of Itraconazole

Answer

Reduced efficacy of Simvastatin

Answer

Increased risk of bleeding

Answer

Hypertensive crisis

ukmla MCQ (SBA): Drug Interaction

A patient taking Simvastatin 40mg at night for hypercholesterolaemia is started on Itraconazole for a fungal nail infection. What is the primary pharmacokinetic interaction of concern?