A 52-year-old woman presents with hypertension, obesity, and easy bruising. Blood tests reveal elevated cortisol levels not suppressed by low-dose dex...

Question

A 52-year-old woman presents with hypertension, obesity, and easy bruising. Blood tests reveal elevated cortisol levels not suppressed by low-dose dexamethasone test. The most likely diagnosis is Cushing's syndrome. According to NICE CKS, which is the best next step in confirming the cause?

Accepted Answer

High-dose dexamethasone suppression test

Answer

Plasma free metanephrines

Answer

MRI brain to look for pituitary adenoma

Answer

Abdominal CT for adrenal tumour

Answer

24-hour urinary free cortisol

NICE CKS Cushing's syndrome MCQ (SBA): Cushing's syndrome

A 52-year-old woman presents with hypertension, obesity, and easy bruising. Blood tests reveal elevated cortisol levels not suppressed by low-dose dexamethasone test. The most likely diagnosis is Cushing's syndrome. According to NICE CKS, which is the best next step in confirming the cause?