A 73-year-old patient presents with a tremor that is worse at rest and improves with activity. He also has a shuffling gait and rigidity. What is the ...

Question

A 73-year-old patient presents with a tremor that is worse at rest and improves with activity. He also has a shuffling gait and rigidity. What is the most likely underlying pathophysiology?

Accepted Answer

Loss of dopaminergic neurons in the substantia nigra pars compacta

Answer

Autoimmune demyelination in the central nervous system

Answer

Degeneration of upper motor neurons

Answer

Excess dopamine in the nigrostriatal pathway

Answer

Bilateral cerebellar lesion

NICE Parkinson’s Disease Guideline MCQ (SBA): Parkinson's Disease

A 73-year-old patient presents with a tremor that is worse at rest and improves with activity. He also has a shuffling gait and rigidity. What is the most likely underlying pathophysiology?